Search for dissertations about: "anticancer study"

Showing result 1 - 5 of 44 swedish dissertations containing the words anticancer study.

  1. 1. Design and Synthesis of Chalcone and Chromone Derivatives as Novel Anticancer Agents

    Author : Christine Dyrager; Göteborgs universitet.; Gothenburg University.; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chalcones; Chromones; Fluorescence; Fluorophore; Cellular imaging; Anticancer; Tubulin; Microtubule; Kinase inhibitors; p38; MEK1; Palladium-mediated reactions; Molecular modeling; Structure-Activity Relationships.;

    Abstract : This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) and as potential fluorophores for live-cell imaging. Conveniently, all structures presented were synthesized from commercially available 2 ́-hydroxyacetophenones. READ MORE

  2. 2. Reactions of Model and Anticancer Active Platinum(IV/II) Complexes - A Kinetic and Mechanistic Study

    University dissertation from Inorganic Chemistry, Chemical Center, Lund University

    Author : Kelemu Lemma; Lunds universitet.; Lund University.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Model Pt II complexes; Anticancer active Pt IV compounds; Cisplatin; Rescue agents; L-Ascorbic acid; Thiol; Substitution; Kinetics and mechanism; Electron transfer; Inorganic chemistry; Oorganisk kemi;

    Abstract : Popular Abstract in Swedish Den kemiskt enkla föreningen cis-[PtCl2(NH3)2)] (cisplatin) används för behandling av vissa cancerformer. Föreningen är i allmänhet giftig för kroppens organ och kroppen utvecklar resistens, vilket begränsar den kliniska effektiviteten. READ MORE

  3. 3. Mitochondria : a target for anticancer therapy

    University dissertation from Stockholm : Karolinska Institutet, Institute of Environmental Medicine

    Author : Björn Kruspig; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Mitochondria possess a central role in several cellular metabolic pathways, maintenance of calcium homeostasis, production of reactive oxygen species (ROS) and in the regulation of various cell death modalities. A majority of cancers demonstrate aberrations in mitochondrial functions, which were shown to contribute to tumourigenesis. READ MORE

  4. 4. Nucleic Acids as Drugs and Drug Targets With Focus on Anticancer Active Platinum Complexes and Small Interfering RNAs

    University dissertation from Department of Chemistry, Lund University

    Author : Hanna Hedman; Lunds universitet.; Lund University.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; siRNA; thermodynamic stability; mass spectrometry; MALDI-MS; chemical probing; luciferase assay;

    Abstract : Popular Abstract in Swedish Titeln på den här avhandlingen är ”Nukleinsyror som läkemedel och mål för läkemedel, med fokus på anticanceraktiva platinaföreningar och små interferande RNA”. Nukleinsyror är mer kända som sina förkortningar DNA och RNA. Anticanceraktiva platinaföreningar är en typ av läkemedel mot cancer. READ MORE

  5. 5. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elin Jonsson; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. READ MORE