Search for dissertations about: "Naturvetenskap Biologiska vetenskaper Biokemi och molekylärbiologi"
Showing result 1 - 5 of 908 swedish dissertations containing the words Naturvetenskap Biologiska vetenskaper Biokemi och molekylärbiologi.
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1. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE
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2. On Transcriptome Sequencing
Abstract : This thesis is about the use of massive DNA sequencing to investigate the transcriptome. During recent decades, several studies have made it clear that the transcriptome comprises a more complex set of biochemical machinery than was previously believed. READ MORE
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3. Functional organisation of the cell nucleus in the fission yeast, Schizosaccharomyces pombe
Abstract : In eukaryotes the genome adopts a non-random spatial organisation, which is important for gene regulation. However, very little is known about the driving forces behind nuclear organisation. READ MORE
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4. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors
Abstract : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. READ MORE
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5. Sperm Membrane Channels, Receptors and Kinematics : Using boar spermatozoa for drug toxicity screening
Abstract : Internal fertilization usually implies that a spermatozoon, with intact attributes for zygote formation, passes all hurdles during its transport through the female genitalia and reaches the oocyte. During this journey, millions to billions of other spermatozoa perish. READ MORE
