Search for dissertations about: "myeloproliferative disorders"

Showing result 1 - 5 of 8 swedish dissertations containing the words myeloproliferative disorders.

2. 1. Angiogenesis in myeloproliferative disorders

   Author : Eva Zetterberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The chronic myeloproliferative disorders, comprising polycythemia vera (PV), essential thrombocytosis (ET), chronic myeloid leukaemia (CML) and myelofibrosis (MF), are all characterized by pathological angiogenesis in variable degrees, e.g. increased microvascular density (MVD) and bizarre vessel architecture. READ MORE

4. 2. Clinical and experimental studies in Philadelphia chromosome negative chronic myeloproliferative disorders

   Author : Peter Johansson; Göteborgs universitet; []
   Keywords : myeloproliferative disorders; polycythaemia vera; essential thrombocythaemia; epidemiology; erythropoietin; red-cell mass; spleen size; thrombo-embolic; PRV-1.;

   Abstract : The present thesis deals with various aspects on the (a) epidemiology, (b) diagnosis, and (c) molecular biology in Philadelphia chromosome negative (Ph-) chronic myeloproliferative disorders (MPD). First, the incidence of the three Ph- MPD, polycythaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF) was investigated in the city of Göteborg, Sweden during the years 1983-1999 (Paper I). READ MORE

5. 3. Clinical and epidemiological studies in myeloproliferative neoplasms

   Author : Malin Hultcrantz; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Myeloproliferative neoplasms (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are clonal hematopoietic disorders characterized by excessive terminally differentiated myeloid cells. MPNs can progress to secondary myelofibrosis or acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS). READ MORE

6. 4. Hyaluronan in normal and malignant bone marrow : a clinical and morphological study with emphasis on myelofibrosis

   Author : Gunnel Sundström; Anna Engström-Laurent; Anders Wahlin; Hans Wadenvik; Umeå universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Hyaluronan; reticulin; fibrosis; chronic myeloproliferative disorders; acute myeloid leukemia; anagrelide; bone marrow; Medicine; Medicin;

   Abstract : Fibrosis in the bone marrow is usually denominated myelofibrosis and may contribute to impaired hematopoiesis. Myelofibrosis is seen both in malignant and non-malignant diseases. READ MORE

7. 5. Human Bone Marrow Microenvironment in Health and Disease

   Author : Sandro Bräunig; Avdelningen för molekylär hematologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic microenvironment; Imaging; Myeloproliferative neoplasms; Spatial relationships; acute lymphoblastic leukaemia ALL ; Fibrosis; Mesenchymal stromal cell; Single cell RNA sequencing;

   Abstract : Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders. READ MORE