Protein phosphorylation cascades regulating islet beta-cell insulin exocytosis through glucose sensing and drug signaling : With special focus on serine/threonine protein phosphates and hypoglycemic sulfonylureas

University dissertation from Stockholm : Karolinska Institutet, Karolinska Institutet, Stockholm Söder Hospital

Author: Mikael Lehtihet; Karolinska Institutet.; Karolinska Institutet.; [2005]

Keywords: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Islet; Insulin; Exocytosis; Protein phosphatase; Protein kinase; CPT-1; Sulfonylurea; Glutamate; Polyphosphoinositide;

Abstract: In human type 2 diabetes, loss of glucose-sensitive insulin secretion from the pancreatic

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