Search for dissertations about: "doctoral thesis of diabetes"

Showing result 1 - 5 of 1652 swedish dissertations containing the words doctoral thesis of diabetes.

  1. 1. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    University dissertation from Units of Epigenetics and Diabetes and Molecular Metabolism, Department of Clinical Sciences, Malmö

    Author : Siri Malmgren; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Abstract : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. READ MORE

  2. 2. The genetic background of gestational diabetes mellitus

    University dissertation from Dept of Diabetes and Celiac Disease

    Author : Anastasia Papadopoulou; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gestational diabetes mellitus; HLA; TCF7L2; PTPN22; Post partum diabetes; Type 1 Diabetes; Type 2 Diabetes; Islet Cell Autoantibodies;

    Abstract : The aims of this work is to better determine the genetic background of gestational diabetes (GDM) and to examine how specific genes affect the development of diabetes post partum. In the DiPiS (Diabetes Prediction in Skåne) study we typed for HLA-DQB1 alleled, the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004. READ MORE

  3. 3. Mechanisms of defective insulin secretion in type 2 diabetes

    University dissertation from Islet patophysiology

    Author : Taman Mahdi; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; Insulin secretion; TCF7L2; ADRA2A; KCNQ1; SFRP4; interleukin-1B;

    Abstract : Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. READ MORE

  4. 4. Study of DNA methylation in human pancreatic islets

    University dissertation from Epigenetics and Diabetes

    Author : Elin Hall; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; epigenetics; DNA mehtylation; human pancreatic islets; insulin secretion;

    Abstract : Today type 2 diabetes is a common disease with a worldwide prevalence of 8.3%. The disease is characterised by hyperglycaemia which is a result of insufficient insulin secretion from the beta-cells in the pancreatic islets as well as an insulin resistance seen in the target tissues. READ MORE

  5. 5. FOXC2 and CAPN10 as candidate genes for obesity, insulin resistance and type 2 diabetes

    University dissertation from Endocrinology

    Author : Emma A Nilsson; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Biomedical sciences; Type 2 diabetes; Genetics; Obesity;

    Abstract : The worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. READ MORE