Search for dissertations about: "Cell scale"

Showing result 1 - 5 of 624 swedish dissertations containing the words Cell scale.

  2. 1. Creating cell microenvironments in vitro

    Author : Patric Wallin; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell migration; lipid bilayers; cell differentiation; liquid handling; surface functionalization; Microfluidics; chemotractant gradients; mammalian cell culture; cell microenvironments; in vitro screening assay;

    Abstract : Stem cells have a great potential to bring about advancements in fields like developmental biology, drug discovery, cancer biology and tissue engineering. In order to be able to use stem cells to their full potential, it is important to have control over their behavior. READ MORE

  4. 2. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism

    Author : Johan Gustafsson; Chalmers tekniska högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genome-scale metabolic modeling; cancer; metabolism; single-cell RNA-Seq;

    Abstract : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. READ MORE

  5. 3. From Tissue Engineering to Engineering Education Research: Designing in vitro cell microenvironments and undergraduate research experiences

    Author : Patric Wallin; Chalmers tekniska högskola; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; teaching research nexus; community of practice; tissue engineering Undergraduate research experiences; cell microenvironments; cell migration; inquiry based learning; surface functionalization; chemotractant gradients; Microfluidics; situated cognition;

    Abstract : This thesis looks at tissue engineering from two perspectives that are closely interconnected with each other: 1) Research in the discipline of tissue engineering that aims to advance our knowledge in the field, and 2) research on how students learn tissue engineering through undergraduate research.In the body, cells are constantly exposed to a concert of different signaling factors that steer their behavior. READ MORE

  6. 4. Stereotyped B Cell Receptors in Chronic Lymphocytic Leukaemia : Implications for Antigen Selection in Leukemogenesis

    Author : Fiona Murray; Richard Rosenquist Brandell; Kostas Stamatopoulos; Gunilla Enblad; Gerard Tobin; Manlio Ferrarini; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukaemia; immunoglobulin genes; somatic hypermutation; stereotyped B cell receptors; antigen selection; Molecular biology; Molekylärbiologi;

    Abstract : Biased immunoglobulin heavy variable (IGHV) gene usage and distinctive B-cell receptor (BCR) features have been reported in chronic lymphocytic leukaemia (CLL), which may reflect clonal selection by antigens during disease development. Furthermore, the IGHV gene mutation status distinguishes two clinical entities of CLL, where patients with unmutated IGHV genes have an inferior prognosis compared to those with mutated IGHV genes. READ MORE

  7. 5. Molecular Mechanisms in Endothelial Cell Differentiation

    Author : Emma Rennel; Pär Gerwins; Lena Claesson-Welsh; Ian Zachary; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; angiogenesis; FGF-2; VEGF-A; signal transduction; in vitro angiogenesis assay; immortalized brain endothelial cells; H-Ras; tetracycline-regulated gene expression; microarray; telomerase immortalized human microvascular endothelial cells; differentiation; Patologi; Pathology; Patologi;

    Abstract : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. READ MORE