Search for dissertations about: "NK-cells"

Showing result 56 - 60 of 258 swedish dissertations containing the word NK-cells.

  2. 56. Expansion and genetic modification of human natural killer cells for adoptive immunotherapy of cancer

    Author : Tolga Sutlu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A century after the initial proposition that the immune system has the capacity to fight against tumors, evading destruction by immune cells is now well recognized as a hallmark of cancer. Recent decades have witnessed extraordinary improvements in the use of immunotherapy against malignancies and adoptive transfer of Natural Killer (NK) cells stands among promising tools in the fight against cancer. READ MORE

  4. 57. Mechanisms influencing natural killer cell recognition of tumour cells

    Author : Monika Enqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK cells with increased functionality. The process leading to gain of function through inhibition is known as NK cell education. READ MORE

  5. 58. Natural killer cells and antibody-mediated effects in human immunodeficiency virus infection

    Author : Susanne Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human immunodeficiency virus (HIV-1) effectively avoids immunologic eradication. Certain characteristics of the virus contribute to this, including the specific targeting of the body s own defense system, the ability to hide in the host cell genome and the vast viral variability. READ MORE

  6. 59. Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology

    Author : Caroline Leijonhufvud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer immunotherapy is a fast-growing field. The natural killer (NK) cells’ innate ability to detect malignant cells and capacity to perform antibody-dependent cellular cytotoxicity (ADCC) together with low risk of inducing side effects makes these cells an attractive tool for cancer immunotherapy. READ MORE

  7. 60. Microscopy-based single-cell in vitro assays for NK cell function in 2-D and 3-D

    Author : Per Erik Olofsson; Björn Önfelt; Khakoo Salim; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biological Physics; Biologisk fysik;

    Abstract : Natural killer (NK) cells are effector cells of the innate immune system that are responsible for mediating cellular cytotoxicity against virally infected or neoplastically transformed cells. NK cell subsets are defined by their expression of certain cell-surface markers, and are usually related to activation and developmental status. READ MORE