Search for dissertations about: "NK-cells"

Showing result 46 - 50 of 258 swedish dissertations containing the word NK-cells.

2. 46. Dissection of immunity controlling spread and growth of Listeria monocytogenes in neuronal cells

   Author : Yuxuan Jin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : L. monocytogenes; nervous system; neuroinvasion; IFN-ã; CSF-1; neuron; NK cells; T cells; MHC;

   Abstract : Listeria monocytogenes is a Grain-positive, facultative intracellular bacterium that causes severe infections in the nervous system of domestic animals and humans. Rhombencephalitis (brainstem encephalitis) due to L. monocytogenes, is a localized brainstem infection that is frequent in ruminants, and has been reported in humans as well. READ MORE

4. 47. Expression of stimulatory and inhibitory molecules in interactions between natural killer cells neurons

   Author : Eva Backström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Nervous system; brain; neuron; NK cells; dorsal root ganglia; hippocampus; NKG2D; RAE 1; MULT1; nerve lesion; influenza virus; MCMV.;

   Abstract : Natural killer (NK) cells are important effector cells of the innate and the early induced immune defense. In the nervous system they appear early during inflammation and have been ascribed a role in clearance of certain viral infections from the brain. NK cells are regulated by multiple signals transmitted via inhibitory and stimulatory receptors. READ MORE

5. 48. Experimental Chagas disease

   Author : John Andersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Trypanosoma cruzi; NK cells; cytotoxicity; IFN-gamma; IL-12; IFN-alpha beta; Chagas disease; polymyositis; myocarditis; genotype dependence and Toll-like receptors.;

   Abstract : The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection and what factors that predispose to a chronic inflammatory disease after T. cruzi infection. READ MORE

6. 49. Immunological recognition and tumor escape mechanisms of ovarian carcinoma

   Author : Håkan Norell; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Tumor immunology; Immune escape; Antitumor immunity; Ovarian carcinoma; NK cells; HLA class 1; LOH; IFN-γ; CTL; HLA-G; HLA-E; Activating receptors; NK cell-based therapy;

   Abstract : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. READ MORE

7. 50. The ontogeny and regulation of human natural killer cells

   Author : Martin A Ivarsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal development, how NK cells are functionally regulated (educated) via the activating receptor KIR2DS1, and how NK cells in our body are affected during the early phase of an acute viral infection. READ MORE