Search for dissertations about: "hplc method development thesis for drugs"
Showing result 1 - 5 of 6 swedish dissertations containing the words hplc method development thesis for drugs.
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1. Development and Validation of HPLC Methods for Analytical and Preparative Purposes
Abstract : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. READ MORE
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2. Amine transaminase: Process development aspects for chiral amine synthesis
Abstract : Many modern drugs contain chiral amine moieties and the need for more efficient processes to synthesize these amines in high optical purity and concentration are greatly demanded by the fine chemical and pharma industry. Amine transaminases (ATA) allow for the direct asymmetric synthesis of optically pure amines from ketone substrates. READ MORE
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3. Aspects of Optimisation of Separation of Drugs by Chemometrics
Abstract : Statistical experimental designs have been used for method development and optimisation of separation. Two reversed phase HPLC methods were optimised. READ MORE
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4. Progress of Weak Affinity Chromatography as a Tool in Drug Development
Abstract : Weak Affinity Chromatography (WAC) is a technology that was developed to analyse weak (KD > 10-5 M) although selective interactions between biomolecules. The focus of this thesis was to develop this method for various applications in the drug development process.Fragment Based Drug Discovery is a new approach in finding new small molecular drugs. READ MORE
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5. Molecularly Imprinted Solid-Phase Extraction and Liquid Chromatography for Biological Samples
Abstract : This thesis focuses on the use of molecularly imprinted polymers as selective sorbents for solid-phase extraction (MISPE). The MISPE methods developed were mainly intended for use with biological samples, such as human urine and blood plasma. READ MORE