Search for dissertations about: "renal cell Chromosomes"

Showing result 1 - 5 of 6 swedish dissertations containing the words renal cell Chromosomes.

  2. 1. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

    Author : Raviprakash Tumkur Sitaram; Göran Roos; Anders Bjartell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; DJ-1; NBS1; PTEN; WT1; cMyc; hTERT; telomerase; Pathology; Patologi; patologi; Pathology;

    Abstract : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. READ MORE

  4. 2. Molecular genetic aspects of renal cell carcinoma development

    Author : Andrei Alimov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Kidney tumor; RCC; LOH; CGH; SKY; PTEN; chromosome 3p; chromosome 10q; chromosome 14q;

    Abstract : Renal cell carcinoma (RCC) is the most common tumor of the renal parenchyma. The aim of this study was to further characterize known as well as new genetic abnormalities in a clinical material of RCC, as well as in established cell lines to gain more information about etiological and progression factors. READ MORE

  5. 3. Molecular genetics of kidney cancer : chromosomal regions of importance in the development of renal cell carcinoma

    Author : Rikard Erlandsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Carcinoma; renal cell Chromosomes; human; pair 3 Chromosome deletion Genes; suppressor; tumor Sequence analysis; DNA. Renal cell carcinoma RCC is a malignancy of the human kidney; occurring most commonlyduring the seventh and eighth decades of;

    Abstract : Renal cell carcinoma (RCC) is a malignancy of the human kidney, occurring most commonly during the seventh and eighth decades of life. The incidence is high in the Nordic countries and the five year survival is 40-50%. Smoking is a risk factor inferring a minor increase in risk. The best established risk factor is obesity. READ MORE

  6. 4. Telomere length : dynamics and role as a biological marker in malignancy

    Author : Ulrika Svenson; Göran Roos; Uwe Martens; Umeå universitet; []
    Keywords : Telomere length; peripheral blood; immune cells; breast cancer; renal cell carcinoma; biological marker; patologi; Pathology;

    Abstract : Telomeres are protective structures at the end of our chromosomes, composed of multiple repeats of the DNA sequence TTAGGG. They are essential for maintaining chromosomal stability by preventing damage and degradation of the chromosome ends. READ MORE

  7. 5. Approaches for the localization and identification of human cancer genes

    Author : Wong-Onn Lui; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CGH; FISH; SKY; karyotyping; SNP array; expression array; VHL-associated pheochromocytomas; hemangioblastomas; familial renal cell carcinoma; constitutional translocation; sporadic follicular thyroid tumors; chromosomal alterations; fusion oncogene; FTCF-PPAR gamma l; PAX8-PPAR gamma l.;

    Abstract : Chromosomal aberrations have been recognized as important observations that underpin the concept of a mutator phenotype in cancer. In this thesis, two basic strategies were applied to map the location of cancer-related genes in several types of cancers. READ MORE