Advanced search

Showing result 1 - 5 of 13 swedish dissertations matching the above criteria.

  2. 1. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Author : Xianghua Zhou; Göteborgs universitet; []
    Keywords : filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Abstract : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. READ MORE

  4. 2. Mechanistic analyses of hepatocyte plasticity

    Author : Nuria Oliva-Vilarnau; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Adult hepatocytes are highly plastic cells which have a molecular toolbox for efficient regeneration. Yet, end stage liver diseases are becoming an increasing clinical burden. READ MORE

  5. 3. Search for MODY and Type 2 diabetes genes

    Author : Markku Lehto; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; mutation; MODY; mitochondrial DNA; MIDD; insulin deficiency; hepatocyte nuclear factor; Gestational diabetes; glucokinase; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Diabetes is a heterogeneous disease influenced by both environmental and genetic factors. Maturity-onset diabetes of the young (MODY) is considered as a subform of Type 2 diabetes, which is inherited in an autosomal dominant fashion and expressed at childhood or early adult life. READ MORE

  6. 4. Growth hormone regulation of LFABP and PPARa. Genes involved in hepatic lipid metabolism

    Author : Linda Carlsson; Göteborgs universitet; []
    Keywords : Growth hormone; fatty acids; rat; hepatocyte; LFABP; C EBPa; PPARa;

    Abstract : Growth hormone (GH) is known to have several important effects in the control of metabolism. The aim of these studies was to investigate how GH regulates genes involved in fatty acid transport and metabolism in the liver and the interaction between GH and fatty acids in this regulation. READ MORE

  7. 5. Studies on function and regulation of the transcription factor C/EBPalpha

    Author : Per Flodby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The transcription factor C/EBPalpha was originally identified as a protein involved in hepatocyte-specific gene regulation. Later, it has been demonstrated that C/EBPalpha is expressed in several other tissues, mainly in adipose cells, lung, intestine, skin and in myeloid cells. READ MORE