Search for dissertations about: "wobble uridine modifications"

Showing result 1 - 5 of 8 swedish dissertations containing the words wobble uridine modifications.

  2. 1. Formation and function of wobble uridine modifications in transfer RNA of Saccharomyces cerevisiae

    Author : Bo Huang; Anders Byström; Monica Rydén-Aulin; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transfer RNA; Modified nucleoside; Elongator complex; Wobble uridine; Decoding; Molecular biology; Molekylärbiologi;

    Abstract : Transfer RNAs (tRNAs) act as adaptor molecules in decoding messenger RNA into protein. Frequently found in tRNAs are different modified nucleosides, which are derivatives of the four normal nucleosides, adenosine (A), guanosine (G), cytidine (C), and uridine (U). READ MORE

  4. 2. Influence of wobble uridine modifications on eukaryotic translation

    Author : Hasan Tükenmez; Anders Byström; Tracy Nissan; Sebastian Leidel; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Elongator is a conserved six subunit protein (Elp1p-Elp6p) complex that is required for the formation of ncm5 and mcm5 side chains at wobble uridines in transfer RNAs (tRNAs). Moreover, loss-of-function mutations in any gene encoding an Elongator subunit results in translational defects and a multitude of phenotypic effects. READ MORE

  5. 3. Functional aspects of wobble uridine modifications in yeast tRNA

    Author : Anders Esberg; Anders Byström; James T. Anderson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Transfer RNA; Modified nucleosides; Elongator complex; Translation; Kluyveromyces lactis γ-toxin; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. READ MORE

  6. 4. Function of wobble nucleoside modifications in tRNAs of Salmonella enterica Serovar Typhimurium

    Author : Peng Chen; Glenn R. Björk; Paul Agris; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; tRNA; wobble nucleoside; frameshifting; translation; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Transfer RNA from all organisms has modified nucleosides and position 34 (the wobble position) is one of the most extensively modified positions. Some wobble nucleoside modifications restrict codon choice (e.g. 5-methylaminomethyl-2-thiouridine, mnm5s2U) while some extend the decoding capacity (e. READ MORE

  7. 5. Physiological consequences of Elongator complex inactivation in Eukaryotes

    Author : Tony Karlsborn; Anders Byström; Hans Ronne; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Elongator complex; wobble uridine modifications; IKBKAP; IKAP; Familial dysautonomia; Untargeted Metabolic profiling.; molekylärbiologi; Molecular Biology;

    Abstract : Mutations found in genes encoding human Elongator complex subunits have been linked to neurodevelopmental disorders such as familial dysautonomia (FD), rolandic epilepsy and amyotrophic lateral sclerosis. In addition, loss-of-function mutations in genes encoding Elongator complex subunits cause defects in neurodevelopment and reduced neuronal function in both mice and nematodes. READ MORE