Search for dissertations about: "Bioinformatik"

Showing result 1 - 5 of 310 swedish dissertations containing the word Bioinformatik.

  1. 1. Rule-based Models of Transcriptional Regulation and Complex Diseases Applications and Development

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Susanne Bornelöv; Jan Komorowski; Claes Wadelius; Joanna Polanska; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

    Abstract : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. READ MORE

  2. 2. Predicting Function of Genes and Proteins from Sequence, Structure and Expression Data

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Torgeir R. Hvidsten; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik;

    Abstract : Functional genomics refers to the task of determining gene and protein function for whole genomes, and requires computational analysis of large amounts of biological data including DNA and protein sequences, protein structures and gene expressions. Machine learning methods provide a powerful tool to this end by first inducing general models from such data and already characterized genes or proteins and then by providing hypotheses on the functions of the remaining, uncharacterized cases. READ MORE

  3. 3. Prediction, modeling, and refinement of protein structure

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Per Larsson; Arne Elofsson; Erik Lindahl; Barry Honig; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein structure prediction; Multiple alignments; Quality assessment; Molecular dynamics; Implicit solvent; Refinement; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; NATURAL SCIENCES Chemistry Theoretical chemistry Bioinformatics; NATURVETENSKAP Kemi Teoretisk kemi Bioinformatik; NATURAL SCIENCES Chemistry Theoretical chemistry Statistical mechanics; NATURVETENSKAP Kemi Teoretisk kemi Statistisk mekanik; Biochemistry; biokemi;

    Abstract : Accurate predictions of protein structure are important for understanding many processes in cells. The interactions that govern protein folding and structure are complex, and still far from completely understood. However, progress is being made in many areas. Here, efforts to improve the overall quality of protein structure models are described. READ MORE

  4. 4. The Nucleosome as a Signal Carrying Unit From Experimental Data to Combinatorial Models of Transcriptional Control

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Stefan Enroth; Jan Komorowski; Claes Wadelius; Rickard Sandberg; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Next generation sequencing; Nucleosome; Histone modification; Transcriptional regulation; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; Bioinformatik; Bioinformatics;

    Abstract : The human genome consists of over 3 billion nucleotides and would be around 2 meters long if uncoiled and laid out. Each human somatic cell contains all this in their nucleus which is only around 5 µm across. This extreme compaction is largely achieved by wrapping the DNA around a histone octamer, the nucleosome. READ MORE

  5. 5. Dynamics of Microbial Genome Evolution

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sean Hooper; Guy Perriére; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; molekylärbiologi; Molecular Biology;

    Abstract : The success of microbial life on Earth can be attributed not only to environmental factors, but also to the surprising hardiness, adaptability and flexibility of the microbes themselves. They are able to quickly adapt to new niches or circumstances through gene evolution and also by sheer strength of numbers, where statistics favor otherwise rare events. READ MORE