Search for dissertations about: "Systemic Lupus Erythematosus"

Showing result 1 - 5 of 122 swedish dissertations containing the words Systemic Lupus Erythematosus.

  1. 1. Dissecting the Genetic Basis of Systemic Lupus Erythematosus The Pursuit of Functional Variants

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Angélica María Delgado Vega; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Systemic Lupus Erythematosus; SLE; Genetic Mapping; Association Studies; Functional Variants; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Systemisk Lupus Erythematosus; SLE; Genetik; Genetisk Association; Funktionella Varianter; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Lupus Eritematoso Sistémico; LES; Estudios de Asociación Genética; Variantes Funcionales; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Medical Genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap;

    Abstract : Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease that primarily affects women during the childbearing years. SLE is characterized by the production of autoantibodies against nucleic acids and their interacting proteins. READ MORE

  2. 2. Murine Systemic Lupus erythematosus : cellular regulation and molecular mechanisms behind the formation of autoantibodies in autoimmune disease

    University dissertation from Stockholm : Stockholm University

    Author : Marta E. Alarcón-Riquelme; Stockholms universitet.; [1994]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cytologi; Cellbiologi; Immunologi;

    Abstract : .... READ MORE

  3. 3. Genetic studies on Systemic Lupus Erythematosus A fine mapping and candidate gene approach

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Veronica Magnusson; Uppsala universitet.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic Lupus Erythematosus; complex disease; linkage analysis; candidate gene; association studies; Genetik; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). READ MORE

  4. 4. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna-Karin B. Lindqvist; Uppsala universitet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Systemic lupus erythematosus; complex diseases; genetic susceptibility; linkage analysis; genome scan; candidate gene; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. READ MORE

  5. 5. The Genetics of Systemic Lupus Erythematosus The Specificity of IRF5 to SLE

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : MV Prasad Linga Reddy; Uppsala universitet.; [2007]
    Keywords : Molecular genetics; Systemic lupus erythematosus; Interferon regulatory factor 5; Transmission-Disequilibrium Test; Family-based association test; Linkage Disequilibrium; Hardy-Weinberg equilibrium; Genetik;

    Abstract : The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, etc. READ MORE