Search for dissertations about: "nasal powder spray"

Found 2 swedish dissertations containing the words nasal powder spray.

  2. 1. Studies on a Novel Powder Formulation for Nasal Drug Delivery

    Author : Nelly Fransén; Erik Björk; Katarina Edsman; Lars Hovgaard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nasal drug delivery; nasal powder spray; interactive mixture; mucoadhesion; sodium starch glycolate; superdisintegrant; bioavailability; clinical trial; Pharmaceutics; Galenisk farmaci;

    Abstract : Nasal administration has potential for the treatment of indications requiring a fast onset of effect or for drugs with low oral bioavailability. Liquid nasal sprays are relatively common, but can be associated with suboptimal absorption from the nasal cavity; this thesis shows that nasal absorption can be significantly enhanced with a dry powder formulation. READ MORE

  4. 2. Studies on the deposition, bioavailability and systemic activity of glucocorticoids in man

    Author : Lars Thorsson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; systemic activity; glucocorticosteroids; lung deposition; systemic availability; inhalation; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered dose inhaler (pMDI), and the uptake process was slower and less complete with the pMDI formulation. READ MORE