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Showing result 6 - 10 of 10 swedish dissertations matching the above criteria.

2. 6. Quality systems to avoid secondary brain injury in neurointensive care

   Author : Lena Nyholm; Per Enblad; Camilla Fröjd; Anders Lewén; Bo-Michael Bellander; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Subarachnoid hemorrhage; Intracranial pressure; Quality register; Checklist; Nursing interventions; Pressure autoregulation; Intracranial compliance; Hyperthermia; Cerebral energy metabolism; Microdialysis and Brain tissue oxygenation.; Neurokirurgi; Neurosurgery;

   Abstract : Outcome after traumatic brain injury (TBI) depends on the extent of primary cell death and on the development of secondary brain injury. The general aim of this thesis was to find strategies and quality systems to minimize the extent of secondary insults in neurointensive care (NIC). READ MORE

4. 7. Brain Tissue Oxygenation in Traumatic Brain Injury : Experimental and Clinical Studies

   Author : Karlis Purins; Anders Lewén; Per Enblad; Oliver Sakowitz; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain tissue oxygenation; Cerebral metabolism; Traumatic brain injury; Cerebral ischemia; Threshold levels; Neurovent-PTO; Microdialysis; Neurosurgery; Neurokirurgi;

   Abstract : Traumatic brain injury (TBI) is a major cause of death and disability. TBI is frequently followed by cerebral ischemia which is a great contributor to secondary brain damage. The main causes of cerebral ischemia are pathophysiological changes in cerebral blood flow and metabolism. READ MORE

5. 8. Aspects on Mechanisms, Treatment and Outcome in Severe Traumatic Brain Injury

   Author : Teodor Svedung Wettervik; Anders Lewén; Per Enblad; Elham Rostami; Lars-Owe Koskinen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoregulation; clinical outcome; energy metabolism; multimodality monitoring; neurointensive-care; traumatic brain injury; Neurokirurgi; Neurosurgery;

   Abstract : Traumatic brain injury (TBI) is a leading cause for mortality and morbidity worldwide. The primary injury has great impact on patient outcome and cannot be cured, but attentive neurointensive care (NIC) may reduce detrimental secondary brain injuries and is the focus of this thesis. READ MORE

6. 9. Neural Stem and Progenitor Cells as a Tool for Tissue Regeneration

   Author : Ulrika Wallenquist; Karin Forsberg Nilsson; Lars Hillered; Karin Holmqvist; Anders Lewén; Johan Bengzon; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatic brain injury; neural stem cells; transplantation; CNS; PNS; progenitor cells; inflammation; CCI; Biochemistry; Biokemi; Neurosurgery; neurokirurgi; Medical Biochemistry; medicinsk biokemi;

   Abstract : Neural stem and progenitor cells (NSPC) can differentiate to neurons and glial cells. NSPC are easily propagated in vitro and are therefore an attractive tool for tissue regeneration. Traumatic brain injury (TBI) is a common cause for death and disabilities. A fundamental problem following TBI is tissue loss. READ MORE

7. 10. Clusterin and Megalin in The Spinal Cord

   Author : Grzegorz Wicher; Hakan Aldskogius; Lars Hillered; Anders Lewen; Robin Franklin; Uppsala universitet; []
   Keywords : Neurosciences; nerve degeneration; hypoglossal nerve; chaperone; apolipoprotein; development; transcription factor; astrocyte; glial differentiation; myelin; cell signalling; Neurovetenskap;

   Abstract : Nerve injury induces up-regulation of the chaperone protein clusterin in affected neurons and adjacent astrocytes but the functional significance of this response is unclear. We find that motor neuron survival is significantly greater in clusterin(+/+) compared to (-/-) mice. READ MORE