Search for dissertations about: "C terminus"

Showing result 31 - 35 of 166 swedish dissertations containing the words C terminus.

  2. 31. Affibody Molecules for PET Imaging

    Author : Joanna Strand; Tolmachev Vladimir; Sten Nilsson; Uppsala universitet; []
    Keywords : Affibody molecules; Molecular imaging; PET; Radiolabelling; HER2; PDGFRβ; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. READ MORE

  4. 32. Studies on the coiled-coil protein TlpA in salmonella : a thermosensing transcription autoregulator

    Author : Reini Hurme; Karolinska Institutet; Karolinska Institutet; []
    Keywords : coiled-coilgene regulationrepressorthermoregulationSalmonella;

    Abstract : The coiled-coil motif is composed of amino acid heptad repeats with hydrophobic or apolar residues at conserved positions. Such repeats are responsible for the apolar stripe that is buried inside the coiled-coil structure formed upon coiling of two (or more) alpha-helical chains about each other. READ MORE

  5. 33. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases

    Author : Terrence Heathfield; Enheten för led- och mjukvävnadsforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; Metabolism; Biochemistry; collagen; fibromodulin; cartilage; osteoarthritis; Biokemi;

    Abstract : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. READ MORE

  6. 34. Development of ADAPT-based tracers for radionuclide molecular imaging of cancer

    Author : Javad Garousi; Vladimir Tolmachev; Tony Lahoutte; Uppsala universitet; []
    Keywords : ADAPT; scaffold protein; albumin-binding domain ABD ; Affinity protein; HER2; radionuclide molecular imaging;

    Abstract : ABD-Derived Affinity Proteins (ADAPTs) is a novel class of small engineered scaffold proteins based on albumin-binding domain (ABD) of streptococcal protein G. High affinity ADAPT  binders against various therapeutic targets can be selected. READ MORE

  7. 35. Interactions Between Small Heat Shock Proteins and Substrate Proteins Mass Spectrometric Detection of Crosslinked Peptides to Map Protein-Protein Interactions

    Author : Emma Åhrman; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interactions; Small heat shock proteins; Mass spectrometric peptide mapping; Proteins; enzymology; Proteiner; enzymologi;

    Abstract : The small heat shock proteins (sHsps) are a widespread class of molecular chaperones existing in all organisms. During heat stress the sHsps protect other proteins from unfolding and aggregation. In plants the sHsps play an especially prominent part of the stress response. READ MORE