Search for dissertations about: "Anna-Karin Sjögren"

Found 1 swedish dissertation containing the words Anna-Karin Sjögren.

  1. 1. The Importance of Isoprenylation and Nf1 Deficiency in K-RAS-induced Cancer

    Author : Anna-Karin Sjögren; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTase; GGTase-I; isoprenylation; K-RAS; NF1; CAAX proteins; lung cancer; AML;

    Abstract : The RAS and RHO family proteins contribute to tumorigenesis and metastasis and belong to a family of so called CAAX proteins. The membrane targeting and proper function of CAAX proteins are dependent on posttranslational isoprenylation by farnesyltransferase (FTase) or geranylgeranyltransferase type I (GGTase-I). READ MORE