Search for dissertations about: "DNA vaccine"

Showing result 21 - 25 of 121 swedish dissertations containing the words DNA vaccine.

  2. 21. Analytical Quality by Design Method Development for Vaccine Characterization

    Author : Lars Geurink; Catharina Sänger van de Griend; Mikael Hedeland; Martijn Schenning; Iulia Oita; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; viral vaccines; adenovirus; influenza; polio; COVID; corona; capillary electrophoresis; analytical quality by design; analytical method development; CGE; icIEF; CZE; crude cell suspension analysis; in-process sample analysis; quality control testing; biopharmaceutical characterization; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Vaccines that are safe, efficacious, and can be rapidly developed are needed to prevent and to react to emerging global infectious disease threats such as influenza, Polio, and Coronavirus diseases. Fast and reliable analytical methods are required without delay to support vaccine process and product development, characterization, and quality control testing. READ MORE

  4. 22. Strategies to enhance the potency of HIV-1 DNA vaccines

    Author : David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite 30 years of intense research on HIV/AIDS, we have yet to arrive at a prophylactic vaccine that confers complete protection. This mission is complicated by the virus’s vast genetic variability and its ability to mask the targets for neutralizing antibodies. READ MORE

  5. 23. Production and delivery of recombinant subunit vaccines

    Author : Christin Andersson; KTH; []
    Keywords : Affibody; Affinity chromatography; Affinity purification; DNA immunization; Expression plasmid; Fusion protein; Hydrophobic tag; Iscoms; Lipid tagging; Malaria; Mammalian cell expression; Recombinant immunogen; Respiratory Syncytial Virus; Semliki Fo;

    Abstract : Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. READ MORE

  6. 24. HIV therapies : from health-related quality of life to DNA levels

    Author : Lars E Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AIDS; antiretroviral therapy; CD4; DNA load; HIV; immunotherapy; viral kinetics; nursing; medical care; quality of life; real-time PCR; rgpl60; RNA load; therapy interruption.;

    Abstract : The treatment of people infected with HIV was revolutionised with the introduction of protease inhibitor based antiretroviral combination therapy. The therapy has greatly reduced the incidence of AIDS and AIDS-related mortality in the industrialised world. READ MORE

  7. 25. Laboratory diagnosis of Bordetella infection : DNA hybridization and PCR validated against serology and culture in a phase 3 vaccine efficacy trial

    Author : Elisabet Reizenstein; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The present study has focused on developing and validating assays alternative to culture for detection of Bordetella pertussis. The sensitivity of culture is comparatively low when compared to serology, varying from 30% to 80%. An attempt to increase this sensitivity was made by development of assays detecting the DNA of the bacteria. READ MORE