Search for dissertations about: "optimized sample preparation"

Showing result 1 - 5 of 25 swedish dissertations containing the words optimized sample preparation.

  2. 1. Development and Investigations of Novel Sample Preparation Techniques : Electrochemical Extraction and Evaluation of Miniaturized Analytical Devices Coupled to Mass Spectrometry

    Author : Gustav Liljegren; Leif Nyholm; Jean Pettersson; Per Sjöberg; Ari Ivaska; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Electrochemical extraction; Solid-phase microextraction; Solid-phase extraction; Microchip; Mass spectrometry; Polypyrrole; Pressurized-fluid extraction; Preconcentration; Electrospray ionization; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Abstract : Different sample preparation steps prior to a detection method are often essential in analytical chemistry. In this thesis, both static extractions and on-line coupled solid-phase extractions have been studied in combination with different detection techniques. READ MORE

  4. 2. Mass Spectrometry-based Neuroproteomics : Deciphering the Human Brain Proteome

    Author : Sravani Musunuri; Jonas Bergquist; Ganna Shevchenko; Jean-Charles Sanchez; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Brain; Proteomics; Mass spectrometry; Alzheimer s disease; Traumatic brain injury; Membrane proteins; Sample preparation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : Mammalian brain is challenging to study due to its heterogeneity and complexity. However, recent advances in molecular imaging, genomics and proteomics have contributed significantly to achieve insights into molecular basis of brain function and pathogenesis of neurological disorders. READ MORE

  5. 3. Occurrence of Traffic-Derived Microplastics in Different Matrices in the Road Environment

    Author : Ida Järlskog; Yvonne Andersson-Sköld; Stephan Wagner; Statens väg- och transportforskningsinstitut; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; non-exhaust particles; tire wear particles; road dust; automated SEM EDX; environmental samples; optimized sample preparation; organic pollutants; street sweeping; traffic-derived microplastics; road simulator;

    Abstract : The prevalence of microplastic contamination has raised concerns about the potential risk and impact on the global environment. Traffic-derived microplastics, i.e., tire wear particles (TWP), polymer-modified bitumen, and road markings contribute to the emissions, and TWP are assumed to be one of the largest sources of microplastic emissions. READ MORE

  6. 4. Selectivity in NMR and LC-MS Metabolomics : The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics

    Author : Albert Elmsjö; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; NMR; LC-MS; HILIC; UHPLC; Q-ToF; selectivity; co-feature ratio; method evaluation; data evaluation; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Until now, most metabolomics protocols have been optimized towards high sample throughput and high metabolite coverage, parameters considered to be highly important for identifying influenced biological pathways and to generate as many potential biomarkers as possible. From an analytical point of view this can be troubling, as neither sample throughput nor the number of signals relates to actual quality of the detected signals/metabolites. READ MORE

  7. 5. Novel microfluidic based sample preparation methods for rapid separation and detection of viable bacteria from blood for sepsis diagnostics

    Author : Sharath Narayana Iyengar; Aman Russom; Jonas Tegenfeldt; KTH; []
    Keywords : microfluidics; Bioteknologi; Biotechnology;

    Abstract : Sepsis is a serious medical condition characterized by a whole-body inflammatory response caused by bloodstream infection. The final stage of sepsis can lead to septic shock, multiple organ failure, and death. In early sepsis, the concentration of bacteria in the bloodstream is typically low, making diagnosis challenging. READ MORE