Search for dissertations about: "Binding Preferences"

Showing result 1 - 5 of 25 swedish dissertations containing the words Binding Preferences.

2. 1. Optical Dyes for Visualization of Structure and Function of Biomolecules and Biological Membranes

   Author : Maria Matson; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Orientation; RNA; Lipid Membranes; Voltage-Sensitive Dyes; Binding Preferences; Cellular Localization; DNA; Spectroscopy; Spectral Properties; Lipophilic Ruthenium Complex;

   Abstract : To visualize the structure and function of biomolecules and biological membranes in the cell, optical dyes are important tools where in particular fluorescent probes provide a sensitive and selective detection. When cellular compartments are investigated it is crucial that the probe selectively binds to the area of interest and not exhibits unspecific binding affinity. READ MORE

4. 2. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins

   Author : Elmar Nurmemmedov; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; function; structure; transcription factor; cancer; affinity; kinetics; Biacore; RNA binding; DNA binding; Wilms tumour WT1 ; zinc finger;

   Abstract : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. READ MORE

5. 3. Xanthophyll Cycle in the Light of Thylakoid Membrane Lipids - Membrane Packing, Curvature Elastic Stress and Enzyme Binding

   Author : Anna Szilagyi; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; steroider; Lipids; steroids; membranes; Lipider; enzymologi; HPLC; laurdan; fluorescence spectroscopy; Proteins; enzymology; Proteiner; curvature elastic stress; enzyme binding; thylakoid membrane; membrane fluidity; lipid packing; histidine; VDE; zeaxanthin; xanthophyll cycle; mebran;

   Abstract : The xanthophyll cycle involves the light-dependent and reversible conversion of violaxanthin to zeaxanthin. The enzyme, violaxanthin de-epoxidase (VDE) catalyses the conversion of violaxanthin to zeaxanthin, via the intermediate antheraxanthin. VDE is a membrane-hosted enzyme during its activity. READ MORE

6. 4. Computational Studies of Enzymatic Enolization Reactions and Inhibitor Binding to a Malarial Protease

   Author : Isabella Feierberg; Modesto Orozco; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Theoretical chemistry; enzyme mechanism; enolate; molecular dynamics; empirical valence bond; glyoxalase I; ketosteroid isomerase; triosephosphate isomerase; malaria; aspartic protease; plasmepsin; linear interaction energy; drug design; Teoretisk kemi; Theoretical chemistry; Teoretisk kemi; Molecular Biotechnology; Molekylär bioteknik;

   Abstract : Enolate formation by proton abstraction from an sp3-hybridized carbon atom situated next to a carbonyl or carboxylate group is an abundant process in nature. Since the corresponding nonenzymatic process in water is slow and unfavorable due to high intrinsic free energy barriers and high substrate pKa s, enzymes catalyzing such reaction steps must overcome both kinetic and thermodynamic obstacles. READ MORE

7. 5. Glycan dependent Helicobacter spp. and Streptococcus oralis binding to mucins in the gastric and oral mucosal niches

   Author : Gurdeep Chahal; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; Streptococcus; diversity; glycosylation;

   Abstract : Helicobacter pylori infects the stomach of half of the world’s population, while Helicobacter suis colonizes pigs and is the most common non-H. pylori Helicobacter species that also infects human stomach. Infection with Helicobacter spp. is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. READ MORE