Search for dissertations about: "Major protease"

Showing result 1 - 5 of 106 swedish dissertations containing the words Major protease.

  2. 1. Design and Synthesis of Malarial Aspartic Protease Inhibitors

    Author : Karolina Ersmark; Anders Hallberg; Michael Rowley; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; malaria; plasmepsin; aspartic protease; protease inhibitor; macrocycle; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. READ MORE

  4. 2. Characterization of auxiliary membrane proteins in the chloroplast of Arabidopsis thaliana

    Author : Lotta von Sydow; Christiane Funk; Wolfgang Schröder; Thomas Pfannschmidt; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Arabidopsis; chaperone; chloroplast; Cytochrome b559; FtsH; membrane proteins; photosynthesis; Photosystem II; protease; PsbY.; Arabidopsis; chaperone; Cytochrome b559; fotosyntes; fotosystem II; FtsH; kloroplast; membranprotein; proteas; PsbY.; biokemi; Biochemistry;

    Abstract : In nature, sessile plants have to adapt to their environment and to the never ending changes they are exposed to. They do so mainly by proteomic and metabolomic changes. In all cells, there are complex networks of auxiliary proteins that are responsible for quality control of all the cell's proteins. READ MORE

  5. 3. Simplified Nonsense: New Methods for Interrogating NMD

    Author : Hanna Alalam; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mRNA degradation; metabolic labeling; nonsense-mediated decay; Major protease; SARS-CoV-2;

    Abstract : Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral replication. READ MORE

  6. 4. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy

    Author : Muhammad Junaid; Jarl ES Wikberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

    Abstract : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. READ MORE

  7. 5. Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design

    Author : Anton Poliakov; Helena Danielson; Boris Turk; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; serine protease; inhibitor; slow-binding; protein purification; Biokemi; Biochemistry; Biokemi;

    Abstract : Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. READ MORE