Search for dissertations about: "antiviral"

Showing result 1 - 5 of 191 swedish dissertations containing the word antiviral.

  1. 1. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets Applications in Antiviral Drug Discovery & Therapy

    University dissertation from Acta Universitatis Upsaliensis : Uppsala universitet

    Author : Muhammad Junaid; Jarl ES Wikberg; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

    Abstract : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. READ MORE

  2. 2. Human adenoviruses new bioassays for antiviral screening and CD46 interaction

    University dissertation from Umeå : Umeå university

    Author : Emma Andersson; Göran Wadell; Sigvard Olofsson; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; CD46; hemagglutination; antiviral; small molecule; screening; MEDICINE Microbiology; immunology; infectious diseases Microbiology Virology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi Virologi;

    Abstract : Adenoviruses are common pathogens all over the world. The majority of the population has at some point been infected with an adenovirus. Although severe disease can occur in otherwise healthy individuals an adenovirus infection is most commonly self limited in these cases. READ MORE

  3. 3. Identification and evaluation of antiviral compounds targeting Rift Valley fever virus

    University dissertation from Umeå : Umeå universitet

    Author : Koushikul Islam; Clas Ahlm; Magnus Evander; Anna K. Överby; Johan Neyts; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rift Valley fever virus; antiviral; assay development; screening; drug discovery;

    Abstract : Rift Valley fever virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease Rift Valley fever (RVF). RVFV causes significant morbidity and mortality in humans and livestock throughout Africa and the Arabian Peninsula. READ MORE

  4. 4. Viperin vs. tick-borne encephalitis virus mechanism of a potent antiviral protein

    University dissertation from Umeå : Umeå University

    Author : Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

    Abstract : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. READ MORE

  5. 5. Viperin, a multifunctional radical SAM enzyme biogenesis and antiviral mechanisms

    University dissertation from Umeå : Umeå University

    Author : Arunkumar Upadhyay; Anna K. Överby; Niklas Arnberg; Richard Lundmark; Michael Beard; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is an interferon-induced antiviral protein. It has three distinct functional domains: the N-terminal domain, the radical SAM (S-adenosylmethionine) domain for binding iron-sulphur cluster, and the C-terminus domain. READ MORE