Search for dissertations about: "PC12 cell"
Showing result 1 - 5 of 38 swedish dissertations containing the words PC12 cell.
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1. The Tyrosine Kinase GTK : Signal Transduction and Biological Function
Abstract : Protein tyrosine kinases play an important role in the regulation of various cellular processes such asgrowth, differentiation and survival. GTK, a novel SRC-like cytoplasmic tyrosine kinase, was recently cloned from a mouse insulinoma cell line and the present work was conducted in order to find a biological function of GTK in insulin producing and neuronal cells. READ MORE
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2. New Approaches for Chemical Analysis of Single Cells and Vesicles
Abstract : Exocytosis is the major cell-to-cell communication process in the nervous system, involving the conversion of an electrical signal (e.g. action potential) to a chemical one. Signaling molecules like neurotransmitters, hormones and/or peptides are stored in vesicles inside the cell. READ MORE
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3. Roles of the Shb and Cbl Proteins in Signal Transduction and Blood Vessel Formation
Abstract : Formation of blood vessels occurs through two processes: vasculogenesis and angiogenesis, which are regulated by various growth factors such as vascular endothelial growth factor, fibroblast growth factor and platelet-derived growth factor. The present study was carried out in order to investigate the roles of the Shb and Cbl proteins in growth factor-mediated signal transduction and blood vessel formation. READ MORE
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4. Anaplastic Lymphoma Kinase mutations and downstream signalling
Abstract : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. READ MORE
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5. Monitoring of Cellular Dynamics with Focus on Electrochemical Detection Techniques
Abstract : This thesis presents work in two main areas of focus, the development of electroanalytical techniques to monitor the dynamics of cellular processes as well as design and fabrication of microelectrode chips for electrochemical detection as well as a prototype microfluidic system to be used for cell analysis and culturing. The electrochemically monitored cellular parameters were the cellular redox environment (CRE), cell adhesion and exocytosis. READ MORE