Search for dissertations about: "levodopa"

Showing result 1 - 5 of 26 swedish dissertations containing the word levodopa.

  1. 1. Automating levodopa dosing schedules for Parkinson’s disease

    University dissertation from Borlänge : Dalarna University

    Author : Ilias Thomas; Högskolan Dalarna.; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Parkinson’s disease; levodopa; symptom assessment; symptom management; dosing algorithms; wearable sensors; microtablets; continuous infusion; FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik; FLOAT - Flexible Levodopa Optimizing Assistive Technology;

    Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disease. Levodopa is mainly used to manage the motor symptoms of PD. However, disease progression and long-term use of levodopa cause reduced medication efficacy and side effects. When that happens, precise individualized dosing schedules are required. READ MORE

  2. 2. New Approaches for Levodopa Treatment in Parkinson’s Disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marina Senek; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Pharmacokinetics; Pharmacodynamics; Population modeling; Levodopa; Carbidopa; Entacapone; Microtablets; Intestinal infusion;

    Abstract : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. READ MORE

  3. 3. Intestinal transport of levodopa : Implications for the therapy of Parkinson's disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dag Nilsson; Uppsala universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa. duodenal Infusion; intestinal permeability; positron emission tomography; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; Neurology; neurologi;

    Abstract : Levodopa has been the basic treatment of patients with Parkinson's disease for the last 30 years. However, with time nearly all patients develop fluctuations in motor performance correlated to levodopa plasma concentrations. READ MORE

  4. 4. Optimizing levodopa dosing routines for Parkinson’s disease

    University dissertation from Borlänge : Dalarna University

    Author : Ilias Thomas; Högskolan Dalarna.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Parkinson’s disease; levodopa; symptom assessment; symptom management; dosing algorithms; wearable sensors; microtablets; continuous infusion; FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik; FLOAT - Flexible Levodopa Optimizing Assistive Technology;

    Abstract : This thesis in the field of microdata analysis aims to introduce dose optimizing algorithms for the pharmacological management of Parkinson’s disease (PD). PD is a neurodegenerative disease that mostly affects the motor functions of the patients and it is characterized as a movement disorder. READ MORE

  5. 5. Pharmacotherapy for Parkinson's Disease - Observations and Innovations

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dag Nyholm; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa; pharmacokinetics; infusion; drug delivery systems; electronic patient diary; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; Neurology; Neurologi;

    Abstract : Pharmacotherapy for Parkinson’s disease (PD) is based on levodopa, the most effective dopaminergic drug. The development of motor complications constitutes the major challenge for new or refined therapies. READ MORE