Search for dissertations about: "peptide nucleic acid PNA ."

Showing result 1 - 5 of 19 swedish dissertations containing the words peptide nucleic acid PNA ..

2. 1. Thermodynamics of Peptide Nucleic Acid Interactions with DNA

   Author : Tommi Ratilainen; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; thermodynamics; enthalpy-entropy compensation; ionic strength; nucleic acids; fluorescence energy transfer; PNA; calorimetry; sequence-specific binding;

   Abstract : Peptide Nucleic Acid (PNA) is a DNA mimic with the natural nucleobases attached to a charge-neutral pseudopeptide backbone. It has remarkably strong and sequence-specific binding affinity to natural nucleic acids (DNA and RNA), mainly attributed to the lack of charge in the PNA backbone. READ MORE

4. 2. Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA

   Author : Pernilla Wittung; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; fluorescence; RecA; homologous recombination; circular dichroism; DNA analogs; -anti-BPDE; spectroscopy; PNA; DNA-protein interactions;

   Abstract : The work presented in this thesis focuses on interactions between nucleic-acids in biological systems, particularly interactions of the promising drug-candidate peptide nucleic acid (PNA), and on protein-DNA intermediates during recombination. Several experimental techniques, mainly circular dichroism and fluorescence spectroscopy, have been used to characterize the interactions of interest. READ MORE

5. 3. PNA and affinity protein tools for selective tumor targeting of radiopharmaceuticals

   Author : Hanna Tano; Amelie Eriksson Karlström; Per-Åke Nygren; Dario Neri; KTH; []
   Keywords : Cancer therapy; targeted radionuclide therapy; affinity proteins; Affibody molecules; CD38; GRPR; HER2; nanobody; peptide; PNA; RM26; pretargeting; Cancerterapi; radionuklid terapi; affinitetsproteiner; affibody molekyler; CD38; GRPR; HER2; nanobody; peptid; PNA; RM26; pretargeting; Biotechnology; Bioteknologi;

   Abstract : Targeted radiotherapy of cancer intends to selectively deliver cytotoxic radionuclides to tumor cells. Affinity proteins of various kinds are explored for this task, and depending on the affinity protein used, different challenges arise. READ MORE

6. 4. A biophysical study of nucleic acid interactions with analogues and drugs

   Author : Ulrica Sehlstedt; Donald M Crothers; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nucleic acids; binding modes; polarised light spectroscopy; linear dichroism; NMR; triple helix; base-pair breathing dynamics; DAPI; porphyrins; quinoxaline derivatives; Biophysics; Biofysik; Biophysics; biofysik;

   Abstract : work presented in this thesis concerns studies on the physicochemical nature of interactions between nucleic acids and small ligands. The outcome of such studies can yield insights at a molecular level into the physiological mechanisms of action of biologically active nucleic-acid binding molecules. READ MORE

7. 5. Cell-penetrating peptides and bioactive cargoes : Strategies and mechanisms

   Author : Kalle Kilk; Ülo Langel; Michael J. Gait; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; delivery; Peptide nucleic acid; Biochemistry; Biokemi;

   Abstract : The cell membrane is an impermeable barrier for most macromolecules. Recently discovered cell-penetrating peptides (CPPs) have gained lot of attention because they can cross the membrane, and even more, carry cargoes with them. How CPPs enter cells is still not clear, while the delivery of different cargoes has been convincingly shown. READ MORE