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Showing result 1 - 5 of 25 swedish dissertations matching the above criteria.

  2. 1. Exocytosis in insulin secreting cells - role of SNARE-proteins

    Author : Jenny Vikman; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

    Abstract : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. READ MORE

  4. 2. Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

    Author : Emma Brolin; Joakim Bergström; Anna Erlandsson; Martin Ingelsson; Arianna Bellucci; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson’s disease; synaptosome; SNARE complex; proximity ligation assay; extracellular vesicles;

    Abstract : Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesis of Parkinson’s disease and dementia with Lewy bodies, collectively known as α-synucleinopathies. Native α-syn is a monomeric presynaptic protein that can act as a molecular chaperone for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. READ MORE

  5. 3. Membrane rafts and its GPI anchored complement inhibitors regulate insulin secretion

    Author : Vini Nagaraj; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Membrane rafts; basal insulin secretion; regulated insulin secretion; CD59; CD55; SNARE proteins; insulin; pancreatic beta cells.;

    Abstract : Type 2 diabetic patients usually exhibit an abnormal lipid profile. One such lipid that is constantly elevated in T2D is cholesterol. At the cellular level, cholesterol aids in tight packing of sphingolipids in certain regions of the plasma membrane and these specialized regions are termed ‘membrane rafts’, which act as signalling hubs. READ MORE

  6. 4. Characterization of Physiological and Pathological Alpha-Synuclein : Implications for Parkinson’s Disease and Related Disorders

    Author : Leire Almandoz Gil; Joakim Bergström; Martin Ingelsson; Kostas Vekrellis; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Alpha-synuclein; Aggregation; Parkinson’s disease; Dementia with Lewy bodies; Oxidative stress; Antibodies; Synapses; SNARE; Molekylär medicin; Molecular Medicine;

    Abstract : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. READ MORE

  7. 5. The assembly of cytosolic lipid droplets and its effect on insulin sensitivity

    Author : Pontus Boström; Göteborgs universitet; []
    Keywords : diabetes; lipid metabolism; insulin resistance; lipid droplets; ADFP; SNARE;

    Abstract : Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation of triglycerides occurs in so-called lipid droplets in the cytosol. READ MORE