Search for dissertations about: "NONMEM"
Showing result 21 - 25 of 48 swedish dissertations containing the word NONMEM.
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21. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies
Abstract : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. READ MORE
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22. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis
Abstract : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. READ MORE
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23. Pharmacometric Methods and Novel Models for Discrete Data
Abstract : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. READ MORE
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24. Pharmacometric Models of Glucose Homeostasis in Healthy Subjects and Diabetes Patients
Abstract : Diabetes is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Several models have been developed for describing the glucose-insulin system. READ MORE
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25. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier : With Focus on Drug Transport Interactions
Abstract : The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. READ MORE