Search for dissertations about: "gene amplification"
Showing result 1 - 5 of 225 swedish dissertations containing the words gene amplification.
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1. Evolutionary Dynamics of Mutation and Gene Transfer in Bacteria
Abstract : The study of bacterial evolution is fundamental for addressing current problems of antibiotic resistance and emerging infectious diseases and lays a solid foundation for successful and rational design in biotechnology and synthetic biology. The main aim of this thesis is to test evolutionary hypotheses, largely based on theoretical considerations and sequence analysis, by designing scenarios in a laboratory setting to obtain experimental data. READ MORE
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2. Genomic profiling of breast cancer by microarray-based technology and bioinformatics
Abstract : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. READ MORE
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3. TARP Promoter-Based Prostate Cancer Gene Therapy : From Development to Application
Abstract : Prostate cancer is one leading cause of cancer-related death among men in Western countries. The standard therapies for localized prostate cancer include radical prostatectomy and radiation therapy. Such measures are relatively effective in the short term, but many patients ultimately relapse. READ MORE
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4. Padlock Probes and Rolling Circle Amplification : New Possibilities for Sensitive Gene Detection
Abstract : A series of novel methods for detection of known sequence variants in DNA, in particular single nucleotide polymorphism, using padlock probes and rolling circle replication are presented. DNA probes that can be circularized – padlock probes – are ideal for rolling circle replication. READ MORE
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5. Microarray Based Gene Expression Analysis in Cancer Research
Abstract : Biotechnological inventions during the 20th century have resulted in a wide range of approaches for explorations in the functional genomics field. Microarray technology is one of the recent advances which have provided us with snapshots of which genes are expressed in cells of various tissues and diseases. READ MORE