Search for dissertations about: "long non-coding RNAs"

Showing result 1 - 5 of 21 swedish dissertations containing the words long non-coding RNAs.

  1. 1. Regulation of TGFβ signaling by long non-coding RNAs and ADP-ribosylation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Panagiotis Papoutsoglou; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; signal transduction; long non-coding RNAs; ADP-ribosylation; transcriptional regulation; chromatin remodeling; Medicinsk vetenskap; Medical Science;

    Abstract : Transforming growth factor β (TGFβ) signaling pathways participate in embryonic development and tissue homeostasis and have a dual role in cancer. TGFβ acts as a tumor suppressor that promotes cell cycle arrest and apoptosis at initial stages of tumorigenesis. READ MORE

  2. 2. Understanding the role of long non-coding RNAs in neuroblastoma development and progression

    University dissertation from Göteborgs universitet

    Author : Sanhita Mitra; Göteborgs universitet.; Gothenburg University.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Long non-coding RNAs; NBAT1; NRSF REST; CASC15; chromosome 6p22; SOX9; USP36; CHD7; p53; CRM1; MDM2;

    Abstract : Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to NB tumor formation. READ MORE

  3. 3. Characterization of non-coding RNAs in cancer

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Per Johnsson; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : While originally though to only code for proteins, it now stands clear that RNA is a multifunctional molecule involved in a great variety of molecular processes. Recent advances in genome-wide platforms have revealed underappreciated roles of non-protein coding RNAs (ncRNAs). READ MORE

  4. 4. Functional analysis of long non-coding RNAs in cancer

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Linda Vidarsdottir; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives and prompted scientists to further look into the involvement of noncoding RNAs (ncRNAs) in development and disease. READ MORE

  5. 5. Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics

    Author : Samudyata Samudyata; Karolinska Institutet.; Karolinska Institutet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile regulators of gene expression, amidst skepticism regarding the biological usefulness of pervasive genomic transcription and its non-coding RNA products prevalent in most eukaryotes. READ MORE