Search for dissertations about: "dose finding"

Showing result 1 - 5 of 144 swedish dissertations containing the words dose finding.

  1. 1. Model-Based Optimization of Clinical Trial Designs

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Camille Vong; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE

  2. 2. Radiofrequency fields exposure, dose and health

    University dissertation from Umeå : Umeå universitet

    Author : Jonna Wilén; Umeå universitet.; [2002]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; electromagnetic fields; SAR; Specific Absorption; subjective symptoms;

    Abstract : The overall aim of this thesis is to increase our knowledge of relevant exposure parameters when discussing possible health implication from exposure to radiofrequency electromagnetic fields (RF), especially effects that might occur at non-thermal levels.In this thesis an effort is made to broaden the exposure assessment and to take the exposure time into account and combine it with the Specific Absorption Rate (SAR) and the field parameters (electric and magnetic field strength) to approach a dose concept. READ MORE

  3. 3. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Matts Kågedal; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PET; positron emission tomography; receptor occupancy; nonlinear mixed effects; NONMEM; optimal design; dose finding; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. READ MORE

  4. 4. Quantifying image quality in diagnostic radiology using simulation of the imaging system and model observers

    University dissertation from Institutionen för medicin och hälsa

    Author : Gustaf Ullman; Linköpings universitet.; Linköpings universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiology; radiation physics; image quality; optimisation; effective dose; chest radiography; MEDICINE Physiology and pharmacology Radiological research Radiological physics; MEDICIN Fysiologi och farmakologi Radiologisk forskning Radiofysik;

    Abstract : Accurate measures of both clinical image quality and patient radiation risk are needed for successful optimisation of medical imaging with ionising radiation. Optimisation in diagnostic radiology means finding the image acquisition technique that maximises the perceived information content and minimises the radiation risk or keeps it at a reasonably low level. READ MORE

  5. 5. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders Kristoffersson; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. READ MORE