Search for dissertations about: "nuclear localization"

Showing result 1 - 5 of 162 swedish dissertations containing the words nuclear localization.

  2. 1. Proton Magnetic Resonance Spectroscopy in Brain Tumors - Clinical Applications

    Author : Isabella Björkman-Burtscher; Lund Diagnostisk radiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiology; Clinical physics; Localization; Abscess; Brain; Tumor; Spectroscopy; Magnetic Resonance; tomography; medical instrumentation; Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering;

    Abstract : Aims: · to present a test phantom and test method for evaluation of proton magnetic resonance spectroscopy (1H-MRS) single volume localization techniques regarding signal contamination; · to describe the introduction of 1H-MRS in the daily routine of a standard MR-unit; · to evaluate the possibilities offered by 1H-MRS to improve preoperative diagnostic accuracy in patients scheduled for stereotactic biopsy of intracranial mass lesions; · to evaluate the possibilities offered by 1H-MRS to improve diagnostics and therapy control in patients with brain abscesses; · to test the hypothesis that 1H-MRS might be useful for differentiation of brain tumors, based on metabolic changes in tissue across brain lesions or surrounding tissue. Results and conclusions: · The test phantom and test method allow quality assessment with good reproducibility. READ MORE

  4. 2. Expression and novel function of CD43 in colon cancer cells

    Author : Christian X Andersson; Göteborgs universitet; []
    Keywords : CD43; leukosialin; sialophorin; mucin; nuclear localization; nuclear signaling; Wnt-signaling; beta-catenin; regulated intramembrane cleavage; RIP; proteolytic cleavage;

    Abstract : CD43 is a transmembrane protein containing an extracellular domain that is extensively O-glycosylated, and a relatively large intracellular domain with a conserved sequence between human, rat and mouse. It is frequently expressed in haematopoietic cell lines where it functions as a regulator of cell adhesiveness, a signal transducer and a cytoskeleton-interacting protein. READ MORE

  5. 3. Radiobiological studies with low energy ionizing radiation - dosimetric aspects

    Author : Gustav Grafström; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; low energy; Radiobiology; dosimetry; cell model; Radiofarmaceutisk teknik; Radiopharmaceutical technology; radiobiologi; Nukleärmedicin; radiobiology; Nuclear medicine; animal model;

    Abstract : Background: During the last 20 years both in vitro and in vivo models have been developed for studies of the cell killing characteristics of low energy electrons, e.g. Auger electrons. This thesis deals with radiobiological effects of radiation from indium isotopes in V79 cells in vitro (Paper I-III) and the rat testis in vivo (Paper IVV). READ MORE

  6. 4. The Adenovirus L4-33K Protein : A Key Regulator of Virus-specific Alternative Splicing

    Author : Heidi Törmänen Persson; Göran Akusjärvi; Stefan Schwartz; Marie Öhman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-33K; adenovirus; splicing; phosphorylation; localization; replication centers; L4-22K; MLTU; DNA-PK; DNA-dependent protein kinase; PKA; cAMP-dependent protein kinase; transcription sites; SR protein; Medical Virology; Medicinsk virologi;

    Abstract : Adenoviruses have been extensively studied in the field of gene regulation, since their genes are subjected to a tightly controlled temporal expression during the virus lifetime. The early-to-late shift in adenoviral gene expression distinguishes two completely different programs in gene expression. READ MORE

  7. 5. Functional Characterization of the Evolutionarily Conserved Adenoviral Proteins L4-22K and L4-33K

    Author : Sara Östberg; Göran Akusjärvi; Stefan Schwartz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-22K; L4-33K; RNA; splicing; adenovirus; nuclear localization; replication; transcription; evolution; SR protein; MLP; promoter; E1A; serotypes;

    Abstract : Regulation of adenoviral gene expression is a complex process directed by viral proteins controlling a multitude of different activities at distinct phases of the virus life cycle. This thesis discusses adenoviral regulation of transcription and splicing by two proteins expressed at the late phase: L4-22K and L4-33K. READ MORE