Search for dissertations about: "preclinical"

Showing result 11 - 15 of 313 swedish dissertations containing the word preclinical.

  2. 11. Preclinical investigation of novel therapies against neuroblastoma

    Author : Karin Hansson; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neuroblastoma; Translational research; Preclinical drug evaluation;

    Abstract : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. READ MORE

  4. 12. Controlled release gel formulations and preclinical screening of drug candidates

    Author : Tofeeq Ur-Rehman; Gerhard Gröbner; Mikael Elofsson; Åsa Gylfe; Martin Malmsten; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; poloxamer; drug delivery; micellization; DMSO; calorimetry; NMR. in situ gelation; chitosan; preclinical pharmacokinetics; type III secretion inhibitors; Physical chemistry; Fysikalisk kemi; Pharmaceutics; galenisk farmaci;

    Abstract : Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. READ MORE

  5. 13. Visualising neurodegeneration in the living brain : Preclinical evaluation of PET radioligands

    Author : Mengfei Xiong; Stina Syvänen; Sahar Roshanbin; Joakim Bergström; Per Borghammer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; Alzheimer s disease; Parkinson s disease; SV2A; neurodegeneration; immunotherapy; transgenic mice; Medicinsk vetenskap; Medical Science; Analytical Chemistry; Analytisk kemi; Pharmacology; Farmakologi; Molekylär medicin; Molecular Medicine;

    Abstract : With an ageing population, the number of people suffering from Alzheimer’s disease (AD) and Parkinson’s disease (PD) escalates yearly. Pathological hallmarks of AD and PD include aggregated proteins and synaptic dysfunction. READ MORE

  6. 14. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

    Author : Ann Tronde; Gerrit Borchard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. READ MORE

  7. 15. Biomarkers in preclinical familial Alzheimer disease

    Author : Steinunn Thordardottir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Alzheimer disease (AD) is a neurodegenerative disorder, characterized by the accumulation of b-amyloid (Ab) plaques and tangles consisting of hyperphosphorylated tauprotein in the brain. It accounts for 60-70% of dementia cases, making it the most common cause of dementia. READ MORE