Search for dissertations about: "protein oligomerization"

Showing result 1 - 5 of 58 swedish dissertations containing the words protein oligomerization.

2. 1. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

   Author : Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

   Abstract : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. READ MORE

4. 2. Investigation of Neuronal Protein Trafficking at the Molecular Scale

   Author : Martina Damenti; Ilaria Testa; Clive Bramham; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Endoplasmic Reticulum; Mitochondria; Arc Activity-regulated cytoskeleton-associated protein ; oligomerization; pRESOLFT; STED; event-triggered FCS; DNA-PAINT; STARSS; molecular dynamics simulations; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

   Abstract : Neurons are polarized cells that encode information in the nervous system viaelectrochemical connections named synapses. The tuning of synapticconnections is enabled by a plastic protein trafficking system which operates atthe nanoscale to finely tweak the neuronal ultrastructure. READ MORE

5. 3. Protein dynamics: aggregation and mechanical unfolding

   Author : Simon Mitternacht; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Monte Carlo simulations; All-atom protein models; Mechanical unfolding; Protein aggregation;

   Abstract : The subject of this thesis is protein dynamics. Papers I--IV and VI study either of two different processes: mechanical unfolding and aggregation. Paper V presents a computationally efficient all-atom model for proteins, variants of which are used to perform Monte Carlo simulations in the other papers. READ MORE

6. 4. Identification and Characterization of Peptides and Proteins using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

   Author : Magnus Palmblad; Ole Nørregaard Jensen; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Materials science; Peptide; protein; peptide mass fingerprinting; identification; sequencing; protein structure; non-covalent interaction; modification; electrospray ionization; liquid chromatography; capillary electrophoresis; electron capture dissociation; Fourier transform ion cyclotron resonance mass spectrometry; cerebrospinal fluid; amyloid β-peptide; Alzheimer’s disease.; Materialvetenskap; Materials science; Teknisk materialvetenskap; Molecular Biotechnology; Molekylär bioteknik;

   Abstract : Mass spectrometry has in recent years been established as the standard method for protein identification and characterization in proteomics with excellent intrinsic sensitivity and specificity. Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. READ MORE

7. 5. Oligomerization of human and bacterial frataxin : Structural and functional studies

   Author : Mostafa Abdalkhalik; Biokemi och Strukturbiologi; []
   Keywords : Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

   Abstract : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. READ MORE