Search for dissertations about: "snail"

Showing result 1 - 5 of 31 swedish dissertations containing the word snail.

  1. 1. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : E-Jean Tan; Uppsala universitet.; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. READ MORE

  2. 2. Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer

    University dissertation from Katja Lundgren

    Author : Katja Lundgren; Lunds universitet.; Lund University.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta-arrestin1; Chk1; Breast Cancer; Tamoxifen; prognostic marker; predictive marker; gene amplification; cyclin D1; EMT; Snail; hypoxia;

    Abstract : Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. READ MORE

  3. 3. Molecular and Cellular Complexity of Glioma Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Demet Çağlayan; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; Sox2; Sox21; Snail; Bone morphogenetic protein; Sleeping Beauty; Gliomatosis Cerebri; T lymphocytes; T regulatory lymphocytes; Oncology; Onkologi; Biology; Biologi;

    Abstract : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. READ MORE

  4. 4. Psychotropic Pharmaceuticals in Aquatic Systems: An Ecological Perspective

    University dissertation from Department of Biology, Lund University

    Author : Melanie Hedgespeth; Lunds universitet.; Lund University.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ecotoxicology; aquatic; trophic level; pharmaceutical; SSRI; beta-blocker; sertraline; fluoxetine; propranolol; fish; daphnia; snail; predator; prey; behavior; life history; multiple stressor;

    Abstract : Popular Abstract in English Psychotropic pharmaceuticals include various groups of chemicals that have been designed to affect neurochemistry in human consumers resulting in changes in cognition, mood, and/or behavior; many target specific receptors and subsequently alter neurotransmitter levels in the central nervous system. The use of pharmaceuticals by consumers results in the release of these active substances and their breakdown products into the environment, the main source of which is through domestic wastewater treatment plants connected to households. READ MORE

  5. 5. TGFβ and LXR signaling in hepatocellular carcinoma

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Claudia Bellomo; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

    Abstract : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). READ MORE